PGenome is a series of 8 programs written in C++ to test the association of segregating sites in candidate genes with phenotypic outcomes. The programs assemble, sort, perform an analysis of genotype frequencies at segregating sites, perform two types of linkage disequilibrium analysis among segregating sites, perform association mapping based upon allele frequencies, and based upon genotypes.

We illustrate the use of PGenome testing for association between segregating sites at the Abundant Trypsin gene in Aedes aegypti with midgut susceptibility to infection with the Dengue-2 virus

PGenome was created to support the "Association Mapping of Segregating sites in the midgut Early Gene and Susceptibility to Dengue-2 virus in the mosquito Aedes aegypti by Norma Gorrochotegui-Escalante, Saul Lozano-Fuentes, Kristine E. Bennett, Barry J. Beaty and William C. Black IV" (submitted to Genetics).

The research was supported by grant R01-AI49256 and NIH Grant U01AI45430. Additional support, NIH Fogarty Center Training Grant D43 TW01130.


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Keywords: associotion mapping, software, pgenome, phenotype, genotype, aedes aegypti

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